I'm sorry that's happening.
The thing that came to mind for me is possibly she is sick or internally injured. That, since pets get very touchy about being handled when they don't feel good. Possibly developing cataracts, so when your hand comes over it surprises/startles her when it gets into range where she can see it (because by that time it might be seen as appearing quickly/as if about to hit).
The other thing, she hasn't been traumatized by another animal inside, or outside (or an accidental jerk on the leash if she ran after something outside) recently, has she (like: just before this behavior started)? Even unexpected surprise/'play' by another pup inside might even do it, if it came at the wrong time. It is possible for pets to develop PTSD as well as humans and be over-reactive to any unexpected movement. (My Omaha did back in the '90s, just from a little kitten that wanted to 'play', but it's idea of play was much rougher and terrorizing than what Omaha liked, so it took a few YEARS after leaving that kitten behind [with my ex] before she calmed down to something closer to what her normal had been.)
I hope she settles down, but you might call the vet to see if s/he thinks that it is worth bringing Boudica in for a look-see.