It astonishes me that there will be a second season this soon, given COVID precautions. However, for those that have seen the behind the scenes series about the Mandalorian, that 360º virtual/video set is AMAZING and - as I think Favreau said in some interview - requires FAR fewer people to actually be ON the set at any given time.
However, it IS a contained space, and those that DO have to be present would be in close quarters. Mando has a mask, as do the Empire troops, but the others present (like Gina's character) would have no protection from airborne particles... and with the exertion needed for large parts of the series, that would be a problem, as that propels spittle particles much further than typical breathing.
However, Disney, with its legal team, I suspect is protecting their actors in any/every way possible. It may also be that the virtual set, because of the heat from millions of LEDs (on all 'six sides' of the round room), has a massively vented soundstage, sucking air through it, up, and out. That would greatly reduce what could hang in the air to potentially infect those actors not encased in polycarbonate.
I am incredibly happy that the second season is almost here. I just hope they all stay healthy enough for a third season.