This show is one of the first I ever saw on [adult swim]. I pretty much loved it from the start. The weird, semi-improvised way all the dialogue is delivered is perfect for the tone they're after, and makes for some very funny (and occasionally very sweet) stuff.
Plus, the show introduced me to H. Jon Benjamin, who I also loved from the start. Coach McGuirk is practically the lifeblood of the show. Particular favorite moments include his pee-filled canteen (always a favorite of my Dad's), his singing on stage while trapped in his car, his effort to stay awake for a week to buy a DVD player, his insistence that no one likes sick people when prompted about the new disabled kid on the soccer team... you know what, pretty much every moment with him is a favorite.
Wish it would come back to Netflix Instant, I'm kinda getting a craving for it right now...