I suggested
Snakes on a Plane earlier but someone theorized the team won't riff it since it's too intentionally comedic. Okay, here's another snake movie that's unintentionally comedic instead.
Sssssss is a ridiculous snake movie made around 1972 or '73. Mad scientist named "Dr. Stoner" - I'm not making this up - plays with snake venom and worships cobras as superior to human beings. Features also include an alcoholic boa constrictor and enough psychedelia to perk my antennae even if snakes had not been involved. See, cobra venom, according to Dr. Stoner, is "one of the world's most powerful hallucigens" (
sic) and as the movie goes on we find injecting it also does other things that are probably fairly predictable at this point.
http://www.imdb.com/title/tt0070622/
Of course, I'd like to see
any bad snake movie done.
Sidenote: I was lucky enough to catch Cinematic Titanic's San Francisco show when they riffed
Rattlers live, and it turned out to be even luckier than I thought it would be because apparently they haven't made a DVD release of it, and I have no idea whether they will or not.
What made that show
really special was I'd written Joel a letter and personally requested that CT riff that film - and about a year later, THEY ACTUALLY WENT AND DID IT...WOW.

I got to meet him, along with Trace and the rest of CT, after the show at the autograph table, and I told him I was that "psychedelic snake chick" who'd suggested that
Rattlers would be an excellent choice since the acting and scripting are so classically bad--and yet as a child I adored this film just because of all the snake action. He shook my hand and gave me a big smile - it made me feel he must've either really loved my note, or the team found the movie eminently riffable. Or both. (Of course, it was probably just a very lucky coincidence.)