Man, I love this show!
It combines the best elements of Jonny Quest, The Tick and all those lame cartoons I watched when I was a kid (Scooby Doo, Fantastic Four).
Season Three kicks off in June, and CN has started to run episodes again to build up excitement.
The creator, Chris McCulloch, worked for The Tick's Ben Edlund while Edlund was doing the Tick animated show. << While I think the Tick was very funny, I HATED the animation of the show. When I was doing some character design for WB animation, we would get Tick model sheets and just groan when we'd see the finished animation. The designs were great but the animation was outsourced to a really weak company. I'm first to admit that some of the WB stuff was really bad too.
Venture Bros was originally written as a comic book series for Monkeysuit, but McCulloch realized it would work better as a cartoon, but he never thought it would get made or accepted. I remember reading a xerox of a pitch for it back around the time of Batman Beyond and thinking it was great but we all doubted anyone would do it without ridiculous censoring. Adult Swim was a perfect place for it.