I'm getting the feeling they're gearing House up for a very tragic end, with him spiraling more and more out of control, and now without Cuddy there for even the promise of getting back together they'll be hard pressed to find anything convincing to anchor the character. Hell, he's practically in a show by himself now. The past few episodes he's only tangentially involved with the team and the cases.
I really don't want to give up on the show, but the end of this season has dropped so far below the beginning in terms of enjoyment its hard to take.