ok so i was thinking about this show last night, and it occured to me (though it probably already occured to most of you) there are a lot of similarities between House (the charectar) and sherlock holmes.
Both have addictions with negative effects, both only take cases based solely on their interest in the overall problem or if they provide puzzles, They both deal rather shortly with people and have no time for politeness. They both have assitants (granted holmes place is taken by three very competant Dr.s)
So anyways i just thought it was interesting.