I really love the show, especially when it truly has something insightful yet incredibly silly to say about politics or religion.
Also, I love how they poked fun at John Edwards(The biggest douche in the universe), Jar Jar(Jakovasauraus), Spielberg and Lucases habit of re-releasing and ruining their classic films(Free Hat), Michael Jackson(The Jeffersons), Satan-Worshipping Animals(Woodland Critter Christmas), Old people driving(Grey Dawn) Mormons(All about the Mormons), Scientology(Trapped in the closet), Mel Gibson(Passion of the Jew) and poking fun at presidential elections(Douche and Turd). There are times when the show really is just too gross and horrid, like in the episode Proper Condom Use or The simpsons already did it. Yeah, sometimes the show can be pretty nasty with the subject matter. That aside however it's a very funny show because the main characters have such great chemistry and they get such crazy ideas or they get too intensely serious about something that it becomes silly... like World of Warcraft. Also the characters purposely go over the top and overreact and don't think nothing of it... they just play it straight ALL the time, which is hilarious to me. The kids act like kids a lot of the time... but characters like Stan and Kyle can be very witty, smart and intelligent, which is great. It is very refreshing to see a show where the main characters are usually pretty smart, even for kids. The best part though is that the ending of every episode is almost always unpredictable unless you've seen it before.