The fry/leela crap too often gets in the way of the funny, so I'd like it to go away.
But it also leads to some of the funniest stuff they have done, if Fry wasn't trying to impress Leela we wouldn't have
The Devil's Hands Are Idle Playthings or Fry slicing up his own brain to drive out the worms or the candy heart thing or a lot of the jokes in that time jumping episode or... well, you get the idea...
Overall the Fry and Leela stuff has lead to more good jokes than lack of jokes, and the show would not be as funny if it didn't have serious moments, that's part of the formula for all long running comedy, and in this show those moments have to come from the relationships, so the setting for the show can be crazy.
And finally, the show works the way it is, extremely few shows get better when they mess around with the characters, so like it or leave it, meat bag. ;-)
Hmmm, think I had too much caffeine this morning....